How can a book tell its own post-publication history? This account of the 1623 edition of Shakespeare's collected plays does that. Everything, from binding to grease spots, from annotations to doodles, can tell us something about how this book has lived multiple lives in different contexts. One person's secular relic kept in an ornamental casket is for another some spare paper for drawing; some copies have been worked on in a scholarly context, others can trace Shakespeare's history on the stage. This biography of a book traces the individual copies of the First Folio across time and space to understand what it has meant to its various owners and users.